CasNo： 62304-98-7
Molecular Formula： C129H215N33O55
Appearance： White powder
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Thymosin alpha 1 is White powder, while it's Molecular Formula is C129H215N33O55. Zadax-in (SciClone).Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying, enhancing, and restoring immune function. Immune enhancing peptideHelps prevent infections such as the common cold or the flu and diseasesReduces inflammation in the bodyAids in the removal of acute or chronic infectionsHas antibacterial, antiviral, and antifungal propertiesSupports the eradication of unhealthy cellsProtects your cells against oxidative stress and damageInhibits viral replicationImprove symptoms associated with chronic fatigueThymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies, as an enhancer of vaccine response, and as a means of curbing morbidity and mortality in sepsis and numerous infections. https://www.ncbi.nlm.nih.gov
The CAS number of Thymosin alpha 1 is 62304-98-7.
More information of Thymosin alpha 1 62304-98-7 are:
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Synonyms |
Thymosina1 (ox);L-Asparagine,N-acetyl-L-seryl-L-a-aspartyl-L-alanyl-L-alanyl-L-valyl-L-a-aspartyl-L-threonyl-L-seryl-L-seryl-L-a-glutamyl-L-isoleucyl-L-threonyl-L-threonyl-L-lysyl-L-a-aspartyl-L-leucyl-L-lysyl-L-a-glutamyl-L-lysyl-L-lysyl-L-a-glutamyl-L-valyl-L-valyl-L-a-glutamyl-L-a-glutamyl-L-alanyl-L-a-glutamyl-;Thymalfasin;Thymosina1 (human);Zadaxin; |
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CAS Number |
62304-98-7 |
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Molecular Formula |
C129H215N33O55 |
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Molecular Weight |
3108.31 |
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Density |
1.360±0.06 g/cm3(Predicted) |
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Boiling Point |
2899.7±65.0 °C(Predicted) |
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PSA |
1456.35000 |
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LogP |
-3.64450 |
Thymosin α1 is an immunomodulator peptide formed from the cleavage of prothymosin α. Thymosin α1 inhibits the growth of 5TGM1 mouse and OPM-2, LP-1, and U266 human multiple myeloma cells in vitro but not in vivo. It also increases CD3- and CD28-induced T cell proliferation in C57BL/KaLwRij splenocytes but not in allogeneic mixed lymphocyte reactions using C57BL/KaLwRij and BALB/c splenocyte co-cultures when used at a concentration of 20 μM. Thymosin α1 also inhibits the growth and migration of H1299, NL9980, and L9981 non-small cell lung cancer (NSCLC) cells that express high levels of programmed cell death ligand 1 (PD-L1) but not of A549 and SPC-A-1 NSCLC cells that express low PD-L1 levels. It also decreases the number of metastatic lesions in a L9981, but not an A549, NSCLC mouse xenograft model when administered at a dose of 20 mg/kg per day. Thymosin α1 (200 μg/kg) increases indoleamine 2,3-dioxygenase 1 (IDO1) expression and IL-10 levels and decreases IL-1β and TNF-α production in the lung in a p.Phe508del mutant cystic fibrosis transmembrane conductance regulator (CFTRF508del/F508del) mouse model of cystic fibrosis and chronic A. fumigatus infection.
InChI:InChI=1/C129H215N33O55/c1-18-59(10)98(159-114(201)76(36-42-91(181)182)146-120(207)83(53-164)154-121(208)84(54-165)155-127(214)99(63(14)166)160-118(205)80(51-94(187)188)152-123(210)95(56(4)5)156-104(191)62(13)135-102(189)60(11)137-115(202)78(49-92(183)184)151-119(206)82(52-163)138-66(17)169)125(212)161-101(65(16)168)128(215)162-100(64(15)167)126(213)147-70(30-22-26-46-133)109(196)150-79(50-93(185)186)117(204)149-77(47-55(2)3)116(203)142-69(29-21-25-45-132)108(195)144-73(33-39-88(175)176)110(197)141-67(27-19-23-43-130)106(193)140-68(28-20-24-44-131)107(194)145-75(35-41-90(179)180)113(200)157-97(58(8)9)124(211)158-96(57(6)7)122(209)148-74(34-40-89(177)178)111(198)143-71(31-37-86(171)172)105(192)136-61(12)103(190)139-72(32-38-87(173)174)112(199)153-81(129(216)217)48-85(134)170/h55-65,67-84,95-101,163-168H,18-54,130-133H2,1-17H3,(H2,134,170)(H,135,189)(H,136,192)(H,137,202)(H,138,169)(H,139,190)(H,140,193)(H,141,197)(H,142,203)(H,143,198)(H,144,195)(H,145,194)(H,146,207)(H,147,213)(H,148,209)(H,149,204)(H,150,196)
Articles related to Thymosin alpha 1:
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Article |
Source |
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Solid phase process for synthesizing peptides |
- , (2008/06/13) |
Sichuan TaiHui Biotechnology Co., Ltd. is located in Chengdu, Sichuan Province. It is an innovative enterprise specializing in the research and development, production and sales of peptides and their derivatives. Our company provides a large number of high-quality spot products such as beauty peptides and customized peptides, and provides impurities and peptide fluorescent labeling, N-terminal modification, N-terminal fatty acid modification, C-terminal modification, phosphorylation modification, methylation modification, multiple pairs of disulfide bonds, amide bond head-to-tail ring, amide bond side chain ring, and branched peptides.